Antibodies

Anti-alpha + beta Synuclein Antibody-Oligo Conjugate

SKU: aoc1153

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Assay

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5'
3'
0/256

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Antibody Target

Target
Alpha-synuclein
UniProt Number
P37840
Additional Target Information
This antibody also binds Beta-synuclein, Uniprot:Q16143.
Target Description
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Molecular Weight
18kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBIF-PELISA
Clone
ARC1181
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
HumanMouseRat
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