Protein–ssDNA Detection by Proximity Ligation Assay
How ssDNA-PLA extends oligo-conjugated proximity ligation from protein–protein interactions to DNA damage repair, detecting RPA2, RAD51, and BLM at resected single-stranded DNA in situ.
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Protein Interaction & Proximity Assays
6 articles • Applications in protein interaction studies
Applications in protein interaction studies and proximity detection using Proximity Ligation Assays (PLA) and related techniques for analyzing molecular interactions in biological systems.
Who Uses PLA Today, and What For? A Literature Landscape Analysis
Where proximity ligation assay research is happening today, who's leading it, and what they're studying — from 10,000+ open-access papers, 2001–2026. Includes an interactive co-authorship network explorer.
Single-Exosome Profiling by Proximity Barcoding Assay
How antibody-oligonucleotide conjugates convert extracellular vesicle surface protein phenotypes into sequencing-readable barcodes using proximity barcoding assay (PBA) for single-vesicle resolution.
DNA Origami and Antibody Oligonucleotide Conjugates
How DNA origami nanostructures combined with antibody-oligo conjugates enable programmable spatial positioning of antibodies for studying membrane protein organization and protein-protein interactions.
Proximity Ligation Assays for Analyzing Protein - Protein Interactions.
Introduction to Proximity Ligation Assays (PLA) Proximity Ligation Assay (PLA) is a highly sensitive molecular biology technique designed to detect and visualize protein-protein interactions directly in cells and tissues.
Proximity Ligation Assay (PLA) Protocol
Complete step-by-step PLA protocol for immunofluorescence format. Includes cell fixation, AOC binding, connector hybridization, rolling circle amplification, fluorescent detection, and troubleshooting guide.
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