Antibodies

Anti-BDNF Antibody-Oligo Conjugate (AMC0122)

SKU: aoc1327

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5'
3'
0/256

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Antibody Target

Target
Neurotrophic factor BDNF precursor form
UniProt Number
P23560
Target Description
Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability..; FUNCTION: [Neurotrophic factor BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity)..
Molecular Weight
28kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
AMC0122
Isotype
lgG2akappa
Form
Liquid
Immunogen
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Mouse
Species Reactivity
MouseRat
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