Antibodies

Anti-CD80 Antibody-Oligo Conjugate

SKU: aoc1594

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Assay

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5'
3'
0/256

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Antibody Target

Target
T-lymphocyte activation antigen CD80
UniProt Number
P33681
Target Description
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed:12121659). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity)..; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B..
Molecular Weight
18kDa/29kDa/33kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBFlow CytometryELISA
Clone
ARC61136
Isotype
IgG
Form
Liquid
Immunogen
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
Human
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