Antibodies

Anti-CLPTM1 Antibody-Oligo Conjugate

SKU: aoc1694

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5'
3'
0/256

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Antibody Target

Target
Putative lipid scramblase CLPTM1
UniProt Number
O96005
Target Description
Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity)..
Molecular Weight
76kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC2720
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
Human