Antibodies

Anti-MAD2L1 Antibody-Oligo Conjugate

SKU: aoc2638

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Assay

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5'
3'
0/256

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Antibody Target

Target
Mitotic spindle assembly checkpoint protein MAD2A
UniProt Number
Q13257
Target Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:15024386, PubMed:29162720). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386)..
Molecular Weight
24kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC0603
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
Human