Antibodies

Anti-Myosin Light Chain 2 Antibody-Oligo Conjugate

SKU: aoc2811

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Assay

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5'
3'
0/256

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Antibody Target

Target
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Number
P10916
Target Description
Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)..
Molecular Weight
19kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBIF-PELISA
Clone
ARC1286
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
MouseRat