Antibodies

Anti-Phospho-eIF4EBP1-T37/T46 Antibody-Oligo Conjugate

SKU: aoc3900

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Assay

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5'
3'
0/256

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Antibody Target

Target
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt Number
Q13541
Target Description
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Molecular Weight
13kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC56491
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human, Mouse, Rat
Host Species
Rabbit
Species Reactivity
HumanRat