Antibodies
Anti-PI3 Kinase p85 alpha/beta Antibody-Oligo Conjugate (ARC57210)
SKU: aoc3100
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Assay
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5'
3'
0/256
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Antibody Target
- Target
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Additional Target Information
- This antibody also binds Phosphatidylinositol 3-kinase regulatory subunit beta, Uniprot:O00459.
- UniProt Number
- P27986
- Target Description
- Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923)..
- Molecular Weight
- 42-54 kDa/81-84 kDa
Antibody Characteristics
- Clonality
- Monoclonal
- Application
- WBELISA
- Clone
- ARC57210
- Isotype
- IgG
- Form
- Liquid
- Immunogen
- Synthetic peptide. This information is considered to be commercially sensitive.
- Immunogen Species
- Human
- Host Species
- Rabbit
- Species Reactivity
- HumanMouse