Antibodies

Anti-PRAS40 Antibody-Oligo Conjugate

SKU: aoc3179

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Assay

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5'
3'
0/256

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Antibody Target

Target
Proline-rich AKT1 substrate 1
UniProt Number
Q96B36
Target Description
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site. In response to insulin and nutrients, AKT1S1 dissociates from mTORC1. Its activity is dependent on its phosphorylation state and binding to 14-3-3. May also play a role in nerve growth factor-mediated neuroprotection.
Molecular Weight
27 kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC1965
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
HumanMouseRat