Antibodies

Anti-Prion protein PrP Antibody-Oligo Conjugate

SKU: aoc3184

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Assay

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5'
3'
0/256

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Antibody Target

Target
Major prion protein
UniProt Number
P04156
Target Description
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Molecular Weight
28kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC1315
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
MouseRat