Antibodies

Anti-SIN3A Antibody-Oligo Conjugate (ARC54250)

SKU: aoc3432

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Assay

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5'
3'
0/256

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Antibody Target

Target
Paired amphipathic helix protein Sin3a
UniProt Number
Q96ST3
Target Description
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Molecular Weight
145kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC54250
Isotype
IgG
Form
Liquid
Immunogen
Synthetic peptide. This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
HumanMouse