Antibodies
Anti-TEAD1/2/3/4 Antibody-Oligo Conjugate
SKU: aoc3585
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Assay
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5'
3'
0/256
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Antibody Target
- Target
- Transcriptional enhancer factor TEF-1
- Additional Target Information
- This antibody also binds Transcriptional enhancer factor TEF-3, Uniprot:Q15561. This antibody also binds Transcriptional enhancer factor TEF-4, Uniprot:Q15562. This antibody also binds Transcriptional enhancer factor TEF-5, Uniprot:Q99594.
- UniProt Number
- P28347
- Target Description
- Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
- Molecular Weight
- 48 kDa/49 kDa/47 kDa
Antibody Characteristics
- Clonality
- Monoclonal
- Application
- WBELISA
- Clone
- ARC1158
- Isotype
- IgG
- Form
- Liquid
- Immunogen
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Immunogen Species
- Human
- Host Species
- Rabbit
- Species Reactivity
- Human