Antibodies

Anti-VHL Antibody-Oligo Conjugate

SKU: aoc3784

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Assay

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5'
3'
0/256

Delivery timeline to be confirmed

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Antibody Target

Target
von Hippel-Lindau disease tumor suppressor
UniProt Number
P40337
Target Description
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
Molecular Weight
24kDa

Antibody Characteristics

Clonality
Monoclonal
Application
WBELISA
Clone
ARC59984
Isotype
IgG
Form
Liquid
Immunogen
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Species
Human
Host Species
Rabbit
Species Reactivity
HumanMouseRat