AntibodiesNeuroMab

Anti-Kv3.1B K+ Channel Antibody-Oligo Conjugate

SKU: aoc21

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Assay

Immunofluorescence Oligossee protocol

IF1 Oligo Details

5'
AATATGGAATTCGTCCGAGCCCGTCAAG
3'

View Paper

Accessory oligo is complementary to only the ab-conjugated oligo

Anti-Kv3.1B K+ Channel Antibody-IF1

Antibody Target

Target
Kv3.1b K+ channel
UniProt Number
P48547
Target Description
Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.
Molecular Weight
110 kDa
Synonyms
Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

Antibody Characteristics

Clonality
Monoclonal
Application
WBIHCICCIP
Specificity
No cross-reactivity reported
Clone
N16B/8
Isotype
IgG1
Form
Liquid
Immunogen
Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122) produced recombinantly in E. Coli
Immunogen Species
Rat
Host Species
Mouse
Species Reactivity
HamsterHumanMonkey (Non-Human Primate)MouseRat