Antibodies
Anti-Phospho-SMAD1-S463/S465+SMAD5-S463/S465+SMAD9-S465/S467 Antibody-Oligo Conjugate
SKU: aoc4057
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Assay
Immunofluorescence Oligossee protocol
IF1 Oligo Details
5'
AATATGGAATTCGTCCGAGCCCGTCAAG
3'
Accessory oligo is complementary to only the ab-conjugated oligo
Anti-Phospho-SMAD1-S463/S465+SMAD5-S463/S465+SMAD9-S465/S467 Antibody-IF1
Antibody Target
- Target
- Mothers against decapentaplegic homolog 1
- UniProt Number
- Q15797
- Additional Target Information
- This antibody also binds Mothers against decapentaplegic homolog 5, Uniprot:Q99717. This antibody also binds Mothers against decapentaplegic homolog 9, Uniprot:O15198.
- Target Description
- Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import.
- Molecular Weight
- 52kDa
Antibody Characteristics
- Clonality
- Monoclonal
- Application
- WBIHCICCELISA
- Clone
- ARC59007
- Isotype
- IgG
- Form
- Liquid
- Immunogen
- A synthetic phosphorylated peptide around S463/S465//S467 of human SMAD1/SMAD5/SMAD9.
- Immunogen Species
- Human
- Host Species
- Rabbit
- Species Reactivity
- HumanMouseRat