At AbOliGo, many customers ask about antibody–oligo conjugates made with random versus site-specific methods. To help, we're publishing a series of short articles that distil key takeaways from landmark publications.
Antibody-oligonucleotide conjugates (AOCs) may be synthesized using a wide range of chemical approaches. These include stochastic methods where protein lysines provide a large number of potential sites.
Antibody-oligonucleotide conjugates (AOCs) are used in techniques such as immuno-PCR, proximity ligation assay (PLA) and proximity extension assay (PEA), and are also being examined as potential therapeutics.
Tags that appear alongside “Methods” in articles.