At AbOliGo, many customers ask about antibody–oligo conjugates made with random versus site-specific methods. To help, we're publishing a series of short articles that distil key takeaways from landmark publications.
Antibody-oligonucleotide conjugates (AOCs) may be synthesized using a wide range of chemical approaches. These include stochastic methods where protein lysines provide a large number of potential sites.
Antibody-Oligonucleotide Conjugate Technology Development. Antibody-oligonucleotide conjugation has revolutionized molecular detection since the 1992 introduction of Immuno-PCR, achieving femtomolar sensitivity.
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